As my boss pointed out earlier this month, the Njardarson group (Cornell) currently has a listing of the 2006 top 200 generic and brand name drugs with structures. You can download the pdf files for your own pleasure or have them blown up to poster size as my group did. (The posters currently reside in our group breakroom, so that even at lunchtime, we never totally leave the realm of medicinal chemistry). It's amazing how many of the drugs that I recognized by name--and of course now it is handy to know their structure. Who knew that the estradiol analog found in many birth control pills contains an alkyne (ethinyl estradiol) that (according to wikipedia) was apparently key in creating a compound resistant to degradation by the liver? Or that the brand name drug Klor-Con (#153 on the list), which made $160,000,000 last year is actually only KCl?
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16 comments:
Ethinyl estradiol I knew, since I can't live without it. The list is pretty cool, though.
Thanks for recognizing our hard work on the posters. If anyone notices any errors on either of them, please email Jon and we will try to keep them up to date. Also keep an eye out for new posters as the new lists come out.
thanks for the link. My labmates have been pouring over it for the past two days.
Very nice table, tx!
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